CUDA kernels are a non starter because they require Nvidia GPUs. Things like CAD software will mostly use some kind of lower common denominator graphics layer like openGL. Webgpu is actually a decent alternative to that.

There certainly are optimisations that aren’t possible in web browsers today. Arbitrary wasm memory constraints and difficulties around cpu multithreading or simd for example. But CUDA kernels aren’t a realistic option for most cad software.