esseph 3 days ago

At a biological level, psilocybin induced a dose-dependent effect on neurogenesis, with a low dose increasing, and a high dose decreasing neurogenesis (62). (Again, mice)

https://pmc.ncbi.nlm.nih.gov/articles/PMC8461007/

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Aurornis 3 days ago

This report has been taken a little out of context. In mice, a lot of things can be shown to stimulate neurogenesis.

Environmental novelty is even know to be correlated with neurogenesis markers in mice, which is a confounding factor when trying to determine if novel mind-altering substances are producing neurogenesis through some novel mechanism, or the mere experience of shaking up their world with drugs is just another novel experience.

That said, this is a good example of a case where we have a lot of research suggesting that mouse neurogenesis studies don’t translate well to humans. See the other well-written comment above as well as the associated article for more on the topic.

Unfortunately “mushrooms cause neurogenesis” has been taken as a given by a lot of mushroom enthusiasts, podcasters, and new age fitness guru types.

robwwilliams 3 days ago

I missed “neurogenesis”. Most effects appears to be subtle changes in architecture of neurons.