Sure. There is a rather extensive toolkit that comes with the basic distribution, https://docs.racket-lang.org/gui/. For that you can use MrEd to build your layouts if you want, https://github.com/Metaxal/MrEd-Designer.

The problem with that approach is that you need to figure out some parts on your own, like state management. If you need that flexibility it's still a good option, or you'd opt for gui-easy, a library on top of the GUI toolkit that adds observables for state management and a more declarative API, https://docs.racket-lang.org/gui-easy/index.html.

I haven't managed to get cross-compilation going but I've had no problem just copying my Racket files to another computer and build there. It's supposed to be possible however, you'll probably manage to figure it out if it's important to you.

The gui-easy library makes it trivial to pack up some small tool in a GUI in a few tens of lines of code. I'm guessing there is a way to prune the binaries but don't really care about it myself, I just go with the default ~20 MB executables.